Research progress of ustekinumab in treatment of moderate-to-severe ulcerative colitis

XU Saifei，DOU Xiaotan，YU Chenggong，WANG Lei

Abstract: As an emerging targeted biologic agent in recent years，ustekinumab （UST） can specifically bind to interleukin（IL）-12 and IL-23，block the activation of downstream proinflammatory factors，and achieve a broad inhibitory effect on ......

Chin J Clin Res,2026,39(4): 493-498.   [PDF]

Advances in the treatment of difficult-to-treat Crohn's disease

MA Jingjing

Abstract: Crohn's disease is a chronic，progressive，and non-specific inflammation of the gastrointestinal tract. Despite a significant increase in available therapeutic agents in recent years，a considerable proportion of patients exhibit an inadequate response or experience a loss of response......

Chin J Clin Res,2026,39(4): 499-502.   [PDF]

• Akkermansia muciniphila：key target for improving ulcerative colitis with active components of Chinese medicine

  LI Xiangxiang，GAO Liulu，ZHANG Zhaojie，LIU Zhongyu，DENG Yuan，YU Xiaohui

  Chin J Clin Res,2026,39(4):503-507. [PDF]

• Resistance mechanisms and coping strategies of CDK4/6 inhibitors in treatment of breast cancer

  CHEN Guo，HU Dandan，ZHANG Xiaoqing

  Chin J Clin Res,2026,39(4):527-532. [PDF]

• Therapeutic effect of Shaoyao sijun jianpi Recipe combined with Chinese medicine enema on patients with

  hormone-dependent ulcerative colitis 

  WANG Ye，ZHANG Yanxia，YANG Xiaoru，KANG Yajun，ZHAO Zhiqiang

  Chin J Clin Res,2026,39(4):508-512. [PDF]

• Clinical efficacy and safety of ustekinumab in biologic-naïve patients with moderate to severe Crohn's disease 

  WANG Ying，LI Ying，SHEN Peng，ZHANG Guotao，QIAO Xiao 

  Chin J Clin Res,2026,39(4):513-516.  [PDF]

• Efficacy of high-intensity interval training and live Bifidobacterium capsules combined with 5-aminosalicylic 

  acid in treating ulcerative colitis  

  YANG Huimin，WANG Xiaoyan，LIU Yunyun，QIAN Qian，CHEN Juan 

  Chin J Clin Res,2026,39(4):517-521. [PDF]

  
  

• Association of the expression levels of STAT and SOCS in mucosal tissues with the severity and prognosis

  in patients with ulcerative colitis    

  WANG Shujiao，LI Hongmei，XUE Zhimin，ZHAO Fengjuan，JIANG Xiaojia，SONG Shuli 

  Chin J Clin Res,2026,39(4):522-526.  [PDF]

  
  

• Application of ultrasound combined with contrast-enhanced ultrasound in the diagnosis of axillary lymph

  node metastasis of breast cancer   

  WANG Xin，TIAN Dan，DU Min

  Chin J Clin Res,2026,39(4):533-537.  [PDF]

• Expression features of TRPS1 in invasive carcinoma of no special type of the breast and its correlation with 

  prognosis   

  WANG Baoying，TONG Yifan，WANG Hui

  Chin J Clin Res,2026,39(4):538-542. [PDF]

• The value of CA15-3，CCL20 and NK cells in predicting recurrence of HER-2 positive breast cancer after

  breast-conserving surgery 

  ZONG Shoukai，CHI Nana，GUO Xiangting，WANG Kai 

  Chin J Clin Res,2026,39(4):543-546.  [PDF]

  
  

• Deep learning visualization model for assisting junior sonographers in differentiating benign and malignant

  breast nodules    

  MAO Xiaoxian，GU Liping，LI Shuo，SHI Lin，ZHONG Lichang 

  Chin J Clin Res,2026,39(4):547-552.  [PDF]